ea0029p1586 | Thyroid (non-cancer) | ICEECE2012
Strusi V.
, Zini N.
, Dallatana D.
, Mastrogiacomo S.
, Parrilli A.
, Giardino R.
, Lippi G.
, Spaletta G.
, Bassoli E.
, Gatto A.
, Iafisco M.
, Sandri M.
, Tampieri A.
, Toni R.
To test the feasibility of reconstructing ex situ an entire bioartificial thyroid gland suitable for transplantation we have bioengineered a rat thyroid lobe using its decellularized stromal / vascular matrix, eventually 3D recellularized with thyroid stem / precursor cells. Sprague-Dawley male rats (220240 g) were used as thyroid donors, and lobe matrixes obtained by freezing / detergent / enzyme processing. Test matrixes were made electrondense and analyzed by m...